IgG DEGRADER

BHV-1300 IgG Bispecific Degrader

BHV-1300 is the lead asset using a novel Molecular Degrader of ExtracellularProtein (“MoDE”) platform technology. BHV-1300 is a potent extracellular Pan-IgG lowering agent with an innovative mechanism of degrading and depleting pathogenic IgG in chronic and acute conditions rather than inhibition. IgG-specificity with BHV-1300 leads to improvements in disease targeting without unintended consequences on other antibodies.

With a differentiated profile, BHV-1300 has the potential for use in various indications, including, but not limited to, neurological disorders, cancer, infectious and autoimmune diseases.

Bispecific Extracellular Protein Degraders
Hepatic ASGPR Receptor Harnessed for Efficient and Safe Removal of Pathogenic Targets – Pan IgG Degradation